pei peg chitosan copolymer coated iron oxide nanoparticles

Polyethyleneimine-coated Iron Oxide Nanoparticles as a …

2019-2-5 · Here, we present a protocol of using polyethyleneimine-coated superparamagnetic iron oxide nanoparticles (PEI-SPIONs) as a vehicle for the targeted delivery of siRNA to macrophages. PEI-SPIONs are capable of binding and completely condensing siRNA when the Fe:siRNA weight ratio reaches 4 and above.

PEG-chitosan-coated iron oxide nanoparticles with high …

2013-2-1 · A magnetic nano-sized carrier for 10-hydroxycamptothecin (HCPT) was prepared by using Fe 3 O 4 nanoparticles as cores and chitosan (CS) as a polymeric shell by a novel reverse ultrasonic emulsification method. Poly(ethylene glycol) (PEG) chains were then coupled onto the magnetic particles (CS-Fe 3 O 4) to improve their biocompatibility (PEG-CS-Fe 3 O 4).HCPT …

PEI-PEG-Chitosan-Copolymer-Coated Iron Oxide ...

PEI-PEG-Chitosan-Copolymer-Coated Iron Oxide Nanoparticles for Safe Gene Delivery: Synthesis, Complexation, and Transfection Abstract Gene therapy offers the potential of mediating disease through modification of specific cellular functions of target cells.

PEI–PEG–Chitosan‐Copolymer‐Coated Iron Oxide …

PEI–PEG–Chitosan‐Copolymer‐Coated Iron Oxide Nanoparticles for Safe Gene Delivery: Synthesis, Complexation, and Transfection ... (NP–CP–PEI) is made of a superparamagnetic iron oxide nanoparticle (NP), which enables magnetic resonance imaging, coated with a novel copolymer (CP–PEI) comprised of short chain polyethylenimine (PEI ...

Surface Modification of Iron Oxide-Based Magnetic …

2020-7-24 · Moreover, PEG-PEI copolymer coated INOPs loaded Dox in a pH-response manner to test the ability of reducing drug efflux in glioma. The IC 50 of INOPs-Dox in C 6-ADR glioma was approximately 3- to 5-times lower than that of free DOX in cells, demonstrating that preventing drug efflux from drug-resistant cells caused enhanced cell death .

PEI-PEG-Chitosan Copolymer Coated Iron Oxide …

PEI-PEG-Chitosan Copolymer Coated Iron Oxide Nanoparticles for Safe Gene Delivery: synthesis, complexation, and transfection. Adv Funct …

:Hexanoyl-Chitosan-PEG ...

Hexanoyl-Chitosan-PEG Copolymer Coated Iron Oxide Nanoparticles for Hydrophobic Drug Delivery : Hsiao, Meng-Hsuan Mu, Qingxin Stephen, Zachary R. Fang, Chen Zhang, Miqin Department of Materials Science and Engineering

PEI-PEG-Chitosan-Copolymer-Coated Iron Oxide ...

J-GLOBAL ID:200902296157037976 Reference number:09A0855758 PEI-PEG-Chitosan-Copolymer-Coated Iron Oxide Nanoparticles for Safe Gene Delivery: Synthesis, Complexation, and Transfection

Chitosan-Coated Iron Oxide Nanoparticles for Molecular …

2011-4-14 · Iron oxide nanoparticles (IONPs) are a new class of nanomaterials which have attracted extensive interest for application in in vivo magnetic resonance imaging (MRI) due to their intrinsic superparamagnetic and biodegradable properties. Performance of the IONPs is largely dependent upon the properties of their surface coatings, which serve to ...

Publications – Veiseh Lab – Omid Veiseh, Rice University

Forrest Kievit, Omid Veiseh, Narayan Bhattarai, Chen Fang, Jonathan Gunn, Donghoon Lee, Richard Ellenbogen, James Olson, and Miqin Zhang, PEI-PEG-Chitosan Copolymer Coated Iron Oxide Nanoparticles for Safe Gene Delivery: synthesis, complexation, and transfection. Advanced Functional Materials, 19 (14); 2244-2251 (2009)

PEI–PEG–Chitosan‐Copolymer‐Coated Iron Oxide Nanoparticles for …

2009-7-16 · PEI–PEG–Chitosan-Copolymer-Coated Iron Oxide Nanoparticles for Safe Gene Delivery: Synthesis, Complexation, and Transfection ... (NP–CP–PEI) is made of a superparamagnetic iron oxide nanoparticle (NP), which enables magnetic resonance imaging, coated with a novel copolymer (CP–PEI) comprised of short chain polyethylenimine (PEI) and ...

PEG-chitosan-coated iron oxide nanoparticles with high …

2012-8-19 · For example, Qu et al. (44) used a dose of 100 μg/mL of PEG-chitosan-coated iron oxide nanoparticles in a toxicity study with the human hepatocellular carcinoma cell line HepG2. In another study ...

Synthesis optimization and characterization of chitosan …

2012-10-6 · In situ synthesis of chitosan-coated magnetic iron oxide nanoparticles. Chitosan-coated magnetic iron oxide nanoparticles (Fig. 1) were in situ synthesized by the coprecipitation of Fe(II) and Fe(III) salts in the presence of chitosan and TPP molecules with some modifications of Kavaz et al. . TPP was used for the cross-linking of low molecular ...

PEI-PEG-Chitosan-Copolymer-Coated Iron Oxide …

Preparation and characterization of PEG/Dextran coated superparamagnetic Iron Oxide (Fe3O4) nanoparticles for biomedical applications Recent progress in nanotechnology and electrochemical methods can be applied to fine control of the size, crystal structure, and surface properties of iron oxide nanoparticles.

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2012-10-24 · PEI-PEG-Chitosan Copolymer Coated Iron Oxide Nanoparticles SafeGene Delivery: synthesis, complexation, transfection.Adv Funct Mater. 2009;19 (14):2244-2251. ChungYI, Kim JC, Kim YH, et al. surfacefunctionalization PLGAnanoparticles chitosan …

siRNA Therapeutics and its Challenges: Recent Advances in …

2022-7-31 · The investigation was done on superparamagnetic iron oxide (SPION) nanoparticles (NPs) coated with chitosan lactate (CL), complexed with TAT peptide, and delivered with dual siRNA duplexes against PD-1 and A2aR. Apt physicochemical features of the produced NPs led to successful results in in vitro and ex vivo studies.

PEI-PEG-Chitosan Copolymer Coated Iron Oxide …

NP-CP-PEI demonstrates an innocuous toxic profile and a high level of expression of the delivered plasmid DNA in a C6 xenograft mouse model, making it a potential candidate for safe in vivo delivery of DNA for gene therapy. Gene therapy offers the potential of mediating disease through modification of specific cellular functions of target cells. However, effective transport of …

PEG-copolymer-coated iron oxide nanoparticles …

PEG-copolymer-coated iron oxide nanoparticles that avoid the reticuloendothelial system and act as kidney MRI contrast agents ... These iron oxide-copolymer nanoparticles have a high PEG density in their coating which may be …

NOVEL PEI-PEG GRAFT COPOLYMER COATING OF IRON …

Typically, the iron oxide core diameter ranges from about 3 to about 10 nm and the diameter of the core and coating combined ranges from about 10 to about 100 nm. Known nanostructures, such as Feridex™ and Resovist™, are negatively charged and have a short blood residence time (human blood half-life of less than 1 hour) precluding them from ...

Physical characterization and in vivo organ distribution of …

2018-3-20 · Citrate-stabilized iron oxide magnetic nanoparticles (MNPs) were coated with one of carboxymethyl dextran (CM-dextran), polyethylene glycol-polyethylene imine (PEG-PEI), methoxy-PEG-phosphate ...

Publication Year: 2019 / Subject: hydrophobicity and …

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Approach to Rapid Synthesis and Functionalization of Iron …

2016-3-4 · Adequate PEG grafting provides steric stabilization for NPs coated with CCP and moderates charge associated toxicity for PEI modified SPIONs. 20 The presence of multiple catechol groups on the chitosan backbone increases the affinity of polymer to the iron oxide core due to the multi-dentate effect. 21

PEI–PEG–Chitosan‐Copolymer‐Coated Iron Oxide …

2009-7-24 · Read "PEI–PEG–Chitosan‐Copolymer‐Coated Iron Oxide Nanoparticles for Safe Gene Delivery: Synthesis, Complexation, and Transfection, Advanced Functional Materials" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.

Polysaccharide-Coated Magnetic Nanoparticles for …

2015-5-20 · Dextran sulfate-coated superparamagnetic iron oxide nanoparticles as a contrast agent for atherosclerosis imaging (2013) Dong Gil You et al. CARBOHYDRATE POLYMERS

PEI-PEG-Chitosan Copolymer Coated Iron Oxide …

2009-7-24 · PEI-PEG-Chitosan Copolymer Coated Iron Oxide Nanoparticles for Safe Gene Delivery: synthesis, complexation, and transfection Adv Funct Mater . 2009 Jul 24;19(14):2244-2251. doi: 10.1002/adfm.200801844.

Superparamagnetic Iron Oxide (Fe3O4) Nanoparticles …

Cathodic electrochemical deposition (CED) is introduced as an efficient and effective method for synthesis and surface coating of superparamagnetic iron oxide nanoparticles (SPIONs). In this way, bare Fe 3 O 4 nanoparticles were electrosynthesized through CED method from aqueous solution Fe 3+ : Fe 2+ chloride (molar ratio of 2 : 1).

Altmetric – PEI-PEG-Chitosan-Copolymer-Coated Iron …

PEI-PEG-Chitosan-Copolymer-Coated Iron Oxide Nanoparticles for Safe Gene Delivery: Synthesis, Complexation, and Transfection Overview of attention for article published in Advanced Functional Materials, July 2009

PEI–PEG–Chitosan‐Copolymer‐Coated Iron Oxide …

2009-7-24 · The chitosan and PEG suppressed the PEI toxicity while PEG also provided the stability. NP-CP-PEI demonstrated an innocuous toxic profile and a high level of expression of the delivered plasmid ...

Hexanoyl-Chitosan-PEG Copolymer Coated Iron Oxide …

2015-3-23 · Nanoparticle (NP) formulations may be used to improve in vivo efficacy of hydrophobic drugs by circumventing solubility issues and providing targeted delivery. In this study, we developed a hexanoyl-chitosan-PEG (CP6C) copolymer coated, paclitaxel (PTX)-loaded, and chlorotoxin (CTX) conjugated iron oxide NP (CTX-PTX-NP) for targeted delivery of PTX to …

Multifunctional PEG-carboxylate copolymer coated …

2018-4-1 · 1. Introduction. The theranostic potential of superparamagnetic iron oxide nanoparticles (SPIONs) with suitable core size, biocompatible coating and surface functionalities have long been acknowledged in specific applications such as MRI contrasting, hyperthermia and targeted drug delivery,, .Their biomedical applicability depends also on the chemical and …

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Forrest Kievit, Omid Veiseh, Narayan Bhattarai, Chen Fang, Jonathan Gunn, Donghoon Lee, Richard Ellenbogen, James Olson, Miqin Zhang (2009). (PEI–PEG–chitosan-copolymer-coated iron oxide nanoparticles for safe gene delivery: synthesis, complexation, and transfection). (14) 19, pp. 2244–2251. Advanced functional materials.

PEI-PEG-Chitosan Copolymer Coated Iron Oxide …

2009-7-1 · 2.1. Nanovector Development. To better illustrate the design scheme and evaluate the efficacy of our DNA delivery system, three nanoparticle (NP) systems were prepared and their abilities to bind and protect DNA and enable DNA transfection were compared: NP coated with (1) high molecular weight PEI (25 kDa) (NP-PEI), (2) PEG grafted chitosan (chitosan-g-PEG) (NP …

PEI-PEG-Chitosan Copolymer Coated Iron Oxide …

2022-3-21 · The presence of the constituent polymers on the prepared nanoparticles was verified by proton NMR (1 H-NMR) (Fig. 2) in D 2 O.The characteristic 1 H-NMR peak of PEG''s ethylene group at δ = 3.65 ppm (peak I) is resolved on the NP-CP spectrum. Peaks associated with chitosan are not visible in the spectra because sample concentrations were low to reduce the …

Hexanoyl-Chitosan-PEG Copolymer Coated Iron Oxide …

2015-4-21 · Nanoparticle (NP) formulations may be used to improve in vivo efficacy of hydrophobic drugs by circumventing solubility issues and providing targeted delivery. In this study, we developed a hexanoyl-chitosan-PEG (CP6C) copolymer coated, paclitaxel (PTX)-loaded, and chlorotoxin (CTX) conjugated iron oxide NP (CTX-PTX-NP) for targeted delivery of PTX to …